Hello TiRohn
I also run several Nextcloud servers.
You can find a good guide at:
https://www.c-rieger.de/nextcloud-installationsanleitung-v1/
It is based on Ubuntu.
The Nextcloud for testing all run in a VM on an Unraid server.
Since I then have several servers and all run with different subdomains, I also have an NPM on the Unraid which then manages the hostnames for me.
One server is in a different location, which makes a backup every night over the network to another server and this works without any problems.
I always say: No backup, no pity…..
Always remember that you also have a backup, because a cloud is not a backup, it can always happen that hardware breaks down….
Greetings Lorenz